Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain
نویسندگان
چکیده
منابع مشابه
Antagonizing Bcl-2′s BH4 domain in cancer
cancer cells, including B-cell and lung cancers, display elevated expression of anti-apoptotic Bcl-2 proteins as a survival strategy to cope with oncogenic stress [1]. In cancer cells, Bcl-2 is loaded with pro-apoptotic BH3-only proteins, thereby not only preventing Bax/Bak activation but also rendering them " primed to death " at the mitochondria. The last decade, different compounds have been...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2017
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgx016